A couple of studies found no benefits of B12 for lowering homocysteine in HD patients, one used oral B12, 2000 g three times per week for 6 weeks, 55 the other used methyl-B12 i.m
Clinicians who do prescribe AOD-9604 in this age group under a documented informed-consent framework should, at minimum, measure standing height and sitting height every 3 months, track height velocity against population norms, assess Tanner stage at each visit, and obtain fasting IGF-1 and IGFBP-3 levels at baseline and every 3 months [18]
This method ensures rapid absorption, allowing the body to utilize the vitamin more efficiently than oral supplements
What they did: Multiple preclinical models (mice, rats) evaluated the combination AOD-9604 + GLP-1 agonist (Semaglutide or Liraglutide)
n = 8), while a second group received 5A-1MQ treatment at 32 mg/kg of active pharmaceutical ingredient (injections of 4 mg 5A-1MQ monochloride salt/mL sterile saline dosed at 10 mL/kg body weight) after being switched from WD to LD (termed the WD/LD-T group
These changes appear repeatedly in structured trials